![]() The second route similarily starts by reducing phenylalanine to phenylalaninol this time using lithium borohydride, then protection of the amineįunctionality with a tert-Butyloxycarbonyl(BOC) group forming a carbamate. Reduction with lithium aluminium hydride affords methamphetamine, all steps proceed with retention of configuration so if one started with D-phenylalanine one would end up with the required (S) enantiomer. Reduced will remove the hydroxyl group aswell. p-Toluenesulfonyl chloride is then used to create the toluenesulfonate ester which when Then proceeds to protect the amine function, with a carbobenzyloxy (Cbz) group. The first method uses Lithium Aluminium Hydride to reduce There are two routes that have been previously investigated and are documented on Rhodiums website and I am sure everyone reading this has seen. Phenylalanine to amphetamine or N-methylamphetamine ![]()
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